Both Naltrexone and Methadone work on the body’s opioid receptors. Methadone activates the receptors that suppress opioid cravings, while Naltrexone binds and blocks them to reduce cravings.
Unlike methadone, naltrexone is not addictive, does not create a euphoric feeling or high, and withdrawal is minimal.
Methadone is typically used as the first phase in medication assisted treatment, while naltrexone is usually prescribed once the individual has been weaned off methadone or Suboxone and is concerned about relapse while well on the road to recovery.
Unlike methadone, which has to be administered in a clinic by a certified methadone doctor, Naltrexone is prescribed as a take-home treatment.
However, individuals taking either of the medications must agree to regular checkups, counseling, and other therapies.